Comparison of Efficacy of Bovine Xenograft with or Without Platelet- Rich Fibrin in Intrabony Defects: A Systematic Review

Abstract

PRF has been associated with biomaterials like bovine xenograft, and it has demonstrated superior efficacy in repairing intrabony defects when compared to bovine xenograft alone, but it remains unclear. The study aims to compare the results of platelet- rich fibrin (PRF) with those of bovine xenograft and bovine xenograft alone in treating intrabony defects. All studies presented PRF with bovine xenograft group exhibited a better result in clinical and radiographic parameters compared to the bovine xenograft alone group, which were the PRF-bovine xenograft group had lower pocket depth, higher clinical attachment level, lower vertical bone loss and depth of defects. Most of the studies showed there were no significant differences in results between the PRF with bovine xenograft group and bovine xenograft alone group in the treatment of intrabony defects. Still, both groups showed a better result on all parameters when compared to baseline. Only one study presented a significant result in all clinical parameters in intrabony defects between the inter-groups, and both groups also showed a better result on all parameters when compared to baseline. Xenograft does not have bone regeneration properties, so PRF combination can promote bone formation since it has numerous growth factors. Nevertheless, the extensive mesh interconnecting pore structure of bovine xenograft facilitates osteoblast migration and angiogenesis. Centrifugation preparation of PRF and bone defect types also determines healing results. Both groups effectively treat intrabony defects, but the PRF-bovine xenograft complex achieves better outcomes than bovine xenograft alone in intrabony defects.