Pengaruh Pemberian Ekstrak Etanol Herba Poguntano (Picria FelTerrae Lour.) Terhadap Profil Lipid Tikus Putih Jantan Dislipidemia:

The effect of Poguntano (PiciaPicriaFelTerraeLour) Ethanol Extract on Lipid Profile of Dyspilidemic Male Rat

Abstract

Latar Belakang: Dislipidemia adalah terjadinya kelainan metabolisme lipid, baik peningkatan maupun penurunan fraksi lipid dalam darah. Kelainan fraksi lipid yang utama adalah kenaikan kadar kolesterol total, kenaikan kadar LDL, kenaikan kadar trigliserida serta penurunan kadar HDL. Tingginya kadar lipid dalam darah dapat menyebabkan terjadinya aterosklerosis, yang ditandai dengan terdapatnya ateroma pada bagian intima arteri yang berisi kolesterol, zat lipoid, dan lipofag. Perkembangan lebih lanjut dari aterosklerosis ini akan menimbulkan komplikasi pada organ target diantaranya jantung dan otak. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol herba poguntano (EEHP) terhadap profil lipid tikus putih jantan dislipidemia (penurunan kadar kolesterol total, kadar trigliserida, kadar LDL dan peningkatan kadar HDL) serta terhadap proses aterosklerosis. Metode Penelitian: Penelitian ini dilakukan terhadap 30 ekor tikus putih jantan yang dibagi dalam 6 kelompok. Kelompok I sebagai kontrol normal, kelompok II sebagai kontrol negatif diberikan Na-CMC dosis 10 ml/kg bb, kelompok III sebagai kontrol positif diberikan atorvastatin dosis 2 mg/kg bb, kelompok IV, V, dan VI sebagai kelompok perlakuan diberi EEHP dosis 75, 150 dan 300 mg/kg bb. Hewan uji diberi induksi pakan tinggi lemak yang berupa campuran kuning telur puyuh, minyak jelantah, dan lemak sapi selama 14 hari berturut-turut untuk mendapatkan hewan uji dislipidemia yang dilanjutkan dengan treatment selama 14 hari berturut-turut. Pengukuran kadar profil lipid dilakukan pada hari ke-28. Hasil: Hasil analisis statistik menunjukkan bahwa EEHP dapat menurunkan kadar kolesterol total, kadar trigliserida, dan kadar LDL serta dapat meningkatkan kadar HDL secara nyata (p < 0,05). Kesimpulan: Berdasarkan hasil diatas, dapat disimpulkan bahwa EEHP mempuyai pengaruh terhadap profil lipid tikus dislipidemia (penurunan kadar kolesterol total, kadar trigliserida, kadar LDL dan peningkatan kadar HDL) serta dapat mencegah proses terjadinya aterosklerosis.

Background: Dysplipidemia is a lipid metabolism dysfunctionsuch as the incline and the decline of blood lipid profile. The main abnormallipid fractionlevel are the increase of total cholesterol level, LDL level, and triglyceride and the decline of HDL level. The high level of blood lipid can cause atherosclerosis with the atheroma in arterial intima that contains cholesterol, lipoid, and lipophage. The advance stage of atherosclerosis can cause complications to target organs such as heart and brain. Objectives: This research aimed to evaluate the effects of herbapurganto (PiciaPicriaFelTerraeLour) ethanol extract on Lipid Profile of Dyspilidemic Male Rat(the decline of total cholesterol level, triglyceride level, LDL level, and the increase of HDL level) and also the atherosclerosis process. Research method: This research was conducted to 30male ratswhich dividedinto 6 groups. Group 1was served as the normal control, Group 2was servedas negative controls which were given 10 ml/kg bb Na-CMC , Group 3 was served as positive controls which were given 2 mg/kg bb of atorvastatin dosage, Group 4, 5, and 6 were served as the treatment group, and administered with EEHP at the dose of 75, 150, and 300 mg/kb bb . The test animals were fedwith high fatdiet using quail yolk, used cooking oil, and cow fat mixture for 14 days consecutively to obtain dyslipidemia subjects and continued with 14 consecutively treatment. The measure of lipid profile was conducted in the 28th day. Finding: The statistical analysis results indicated that EEHP could decrease the total of cholesterol level, triglyceride level, LDL level, and also it could increase the HDL level (p < 0.05). Conclusion: Based on the results, it could be concluded that EEHP haseffect towards dyslipidemia rat(the decline of total cholesterol level, triglyceride level, LDL level, and the increase of HDL level) and it could also prevent atherosclerosis.